Though raised as siblings by Queen Tuya (Sigourney Weaver) and Pharaoh Seti (John Turturro), Moses (Christian Bale) and Ramses (Joel Edgerton) are ultimately separated by fate and ideology, forever changing themselves and the course of history in the process.

As they grow into their respective roles as national leaders, Moses will need to soften Ramses' hardened heart through demonstrations of God's power, including the famous 12 Plagues, if he is to lead the Jewish people out of Egypt and slavery towards freedom and the land of Israel.