Set four years since the events of the first film, when Jack Reacher (Tom Cruise) returns to the headquarters of his old military unit, he finds out his former Army Major, Susan Turner (Cobie Smulders), has been arrested for treason.

Believing her to be innocent, Jack must break her out of prison in an effort to discover the truth. Meanwhile, Jack is framed for the murder of an old acquaintance, and when he discovers her 15-year-old daughter Samantha (Danika Yarosh) is in danger, he goes on the run with the girl and Turner, as they uncover a conspiracy that is bigger than all of them.