Harvard symbologist Robert Langdon (Tom Hanks) wakes up in a hospital room in Florence, Italy, with no memory of what has happened in the past few days. Suddenly, he finds himself the target of a manhunt. With the help of Dr. Sienna Brooks (Felicity Jones) and his knowledge of symbology, he must foil a deadly global genocide scheme.

He follows clues in Dante's Alighieri's The Divine Comedy and is taken to Florence and Venice, where he must race across a landscape of classic art, secret passageways, and futuristic science, all while solving the most intricate riddle he's ever come across.

Based on the book by Dan Brown.