In 2024, an aged and rugged Logan (Hugh Jackman), along with Professor Charles Xavier (Patrick Stewart), must cope with the loss of the X-Men when a corporation led by Nathaniel Essex is destroying the world. Logan's mutant healing abilities are slowly fading away and Xavier is succumbing to Alzheimer's.

When an 11-year-old mutant girl named Laura Kinney (Dafne Keen) with her own superhuman powers comes into his life, Logan must protect her. Logan, Laura and Professor Xavier must defeat Nathaniel Essex. The trio flee for the Mexican border, in an attempt to keep Laura away from an evil corporation called Transigen.