Mental Madilo is the story of Aravind Krishna and Swetcha who have completely opposite personalities. Whilst, Aravind is always confused about the daily things he does in life; right from picking the clothes to wear to choosing his life partner, Swetcha is a clearheaded and confident woman. As the two meet and fall in love, life goes on smoothly, until Aravind has to go Mumbai where he faces many problems. What happens in Mumbai and how he tackles the problems, forms the crux.