U.S. Army Corps engineer and astronaut Roy McBride (Brad Pitt) embarks on a search across the galaxy for his long-lost scientist father, Clifford McBride (Tommy Lee Jones), who didn't return from a mission to find alien life 20 years earlier.

Despite having been declared dead many years ago, Clifford is found and his reappearance appears to be connected to a series of mysterious explosions and a top-secret military project. As Roy makes his way across a series of increasingly dangerous outposts on the Moon and Mars, forces converge to stop him from finding answers to his father's failed mission, while another impending explosion threatens to destroy life as we know it.