When soldier Ray Garrison (Vin Diesel) is killed on duty, he's brought to the RST corporation, where he's brought back to life. The facility rebuilds all the "assets" in the U.S. military. Ray is the first they've successfully brought back, and he's not not only improved, but enhanced with superpowers as the superhero Bloodshot. The nanotechnology that runs through his veins makes him not only as strong as an army, but it heals him instantly when he's wounded.

However, much to the dismay of the officials at RST, Ray has memories of his beautiful wife, Gina, whom he believes was kidnapped and murdered. The memories instill in him a thirst for revenge, to find and kill the man responsible. However, RST has control not only over his body, but his mind and memories as well. Ray has to figure out what's real and what's not.

Based on the bestselling comic book.