In Wyoming, shortly after the Civil War, bounty hunter John Ruth (Kurt Russell) is escorting a prisoner, Daisy Domergue (Jennifer Jason Leigh) to Red Rock by stage coach to be hanged. They're joined on the coach by another bounty hunter, Major Marquise Warren (Samuel L. Jackson), who carries with him a letter from Abraham Lincoln and a Confederate soldier, Mannix (Walton Goggins).

A blizzard forces the stagecoach to make a stop at Minnie's Haberdashery, where the passengers encounter four sketchy strangers: Mexican Bob (Demian Bichir), flamboyant Oswaldo Mobray (Tim Roth), cowboy Joe Gage (Michael Madsen), and Confederate General Sanford Smithers (Bruce Dern). What follows are squabbles, violence and gunplay.