Rick Mitchell (voiced by Danny McBride) once had a perfect relationship with his daughter Katie (voiced by Abbi Jacobson.) Now that she's a teenager who's been accepted into film school, Rick feels disconnected as Katie spends all her time on her electronics. As a way to reconnect, Rick decides to take the whole family across the country to drive Katie to college and bond one last time.

Katie and Rick are joined by Katie’s wildly positive mom Linda (voiced by Maya Rudolph), her quirky little brother Aaron (voiced by Mike Rianda), and the family’s delightfully chubby pug Monchi for the ultimate family road trip. However, the Mitchells’ plans are interrupted by a tech uprising: all around the world, the electronic devices people love – from phones, to appliances, to an innovative new line of personal robots – decide it’s time to take over. With the help of two friendly malfunctioning robots, the Mitchells will have to get past their problems and save humankind from total domination.