In a dystopian future where pain ceases to exist and the human species adapts to a synthetic environment, the body undergoes new transformations and mutations. With his partner Caprice (Léa Seydoux), celebrity performance artist Saul Tenser (Viggo Mortensen) publicly showcases the metamorphosis of his organs in avant-garde performances.

Timlin (Kristen Stewart), an investigator from the National Organ Registry, obsessively tracks their movements, which is when a mysterious group is revealed… Their mission – to use Saul’s notoriety to shed light on the next phase of human evolution.