A group of life-long friends (Susan Sarandon, Megan Mullally and Sheryl Lee Ralph) travel to Key West, Florida, to be bridesmaids in the surprise wedding of their best college girlfriend Marilyn (Bette Midler). Over the course of one outrageous trip, sisterhoods are rekindled, the past resurfaces, and there are enough sparks, raunch, and romance to change all their lives in unexpected ways.