Exiled American agent Lucas Reyes (Josh Hartnett) is given one last chance to redeem himself - the assignment is to track down and identify a mysterious, international high-value asset known only as The Ghost on a flight from Bangkok to San Francisco.

Complicating matters, the plane is filled with assassins from around the world who are assigned to kill them both. The pair must work together in a fight for their lives. At 37,000 feet, the stakes have never been higher.