College student Stefanie (Kaitlyn Santa) has been experiencing recurring violent nightmares. These nightmares are premonitions that foretell the demise of her family members. Stefanie returns to her hometown to find the one person who might be able to break the cycle and save her family from the inevitable fate—Death—that awaits them.

The story is connected to a woman who managed to escape Death before the events of the original Final Destination movie. This woman has since had a family, but Death is now catching up to claim the lives of those who were never meant to exist.