Mr. and Mrs. Fox (George Clooney and Meryl Streep) live an idyllic home life with their son Ash (Jason Schwartzman) and visiting young nephew Kristofferson (Eric Anderson). But after twelve years of quiet domesticity, the bucolic existence proves too much for Mr. Fox's wild animal instincts. Soon he slips back into his old ways as a sneaky chicken thief and in doing so, endangers not only his beloved family, but the whole animal community. Trapped underground without enough food to go around, the animals band together to fight against the evil Farmers—Boggis, Bunce and Bean—who are determined to capture the audacious, fantastic Mr. Fox at any cost. In the end, he uses his natural instincts to save his family and friends.

Based on the best-selling children's book by Roald Dahl.